More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
SARS-Cov-2 infection in cancer patients, susceptibility, outcome and careArticle Published on 2022-11-012022-11-15 Journal: The American journal of the medical sciences [Category] COVID19(2023년), SARS, 진단, [키워드] anti-cancer treatment antibody benefit Cancer Cancer patients cancers Care coronavirus COVID-19 COVID-19 pandemic doses Factor generate healthy hematologic impacted implication increased risk individuals Infection knowledge observation outcome Pandemics Patient patients Perception problem response to vaccination risk SARS-CoV-2 SARS-COV-2 infection shown susceptibility Vaccines. virus [DOI] 10.1016/j.amjms.2022.05.017 PMC 바로가기
Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19Article Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants [DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기
Potential intestinal infection and faecal-oral transmission of human coronavirusesArticle Published on 2022-11-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome circulating close contact common cold coronavirus coronavirus disease COVID-19 described detectable develop Evidence faecal-oral transmission highlight Human human coronavirus human coronaviruses in vitro in vivo Infection intestinal intestinal infection. manifestation MERS MERS-CoV Middle East occur Occurrence Patient Potential proportion provided Respiratory disease respiratory droplet SARS-CoV SARS-CoV-2 shown Spread Symptoms syndrome Transmission Viral RNA [DOI] 10.1002/rmv.2363 PMC 바로가기
Frequency of SARS-CoV-2 infection in dogs and cats: Results of a retrospective serological survey in Šumadija District, SerbiaArticle Published on 2022-11-012022-11-15 Journal: Preventive veterinary medicine [Category] SARS, 치료기술, [키워드] 95% confidence interval analyzed association bats close contact companion animal conducted coronavirus COVID-19 pandemic District ELISA epidemiological FIVE Frequency household contact Human identify Infection Infectious disease positive reported Research Result retrospective Retrospective study Risk factors SARS-CoV-2 SARS-COV-2 infection serological survey serology Serosurvey Stray dogs and cats. Šumadija susceptible tested through contact Transmission virus virus virus transmission with COVID-19 [DOI] 10.1016/j.prevetmed.2022.105755 PMC 바로가기
Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and ThailandArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect Africa Antibody Response Antigen collected coronavirus coronavirus coronavirus disease Coronaviruses country COVID-19 COVID-19 pandemic distribution Endemic HIV-1 human SARS-CoV-2 IgG response immune response Kenya less Middle East monoclonal antibody much higher Nigeria nucleocapsid protein participant Participants populations Profiling Protein respiratory infections respiratory syndrome coronavirus response SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike screened Serosurvey serum and plasma severe acute respiratory syndrome coronavirus 2 significantly more subunit tested Thailand the receptor-binding domain Uganda Vaccine viruses zoonoses zoonoses. [DOI] 10.3201/eid2811.221041 PMC 바로가기
Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘Article Published on 2022-10-282022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] analysis Analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles [DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in PennsylvaniaArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha analyzed animal reservoir bat coronavirus coronavirus COVID-19 epidemic creating deer Delta Delta variants Epidemics example future infection genomic data help Host Human humans identify independent Infection information Lineage mammals management Multiple nasal swab North America observation occur Odocoileus Odocoileus virginianus positive replicate reported reservoir RT-qPCR SARS-CoV-2 SARS-CoV-2 pandemic significantly spike gene susceptible trajectory Transmission transmissions variant vertebrates white-tail deer white-tailed deer whole genome sequence zoonosis zoonosis. [DOI] 10.1128/mbio.02101-22 PMC 바로가기